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N.O. LIPKOVSKA, O.O. KAZAKOVA, and V.M. BARVINCHENKO

Physicochemical Properties of Curcumin in Aqueous Solutions of Ethonium—a Pharmacologically Active Cationic Dimeric Surfactant
1053–1064 (2024)

PACS numbers: 64.75.Bc, 64.75.Yz, 78.40.Me, 78.67.Ve, 82.70.Uv, 87.85.Qr, 87.85.Rs

Common patterns of changes in the physical and chemical properties of curcumin in solutions of ethonium—a pharmacologically active cationic dimeric surfactant, are revealed. Spectral characteristics, solubility, keto-enol tautomeric equilibrium of curcumin depend on the concentration of ethonium in aqueous solutions and change sharply, when the critical concentration of micellar formation is exceeded. The concentration ranges of surfactant solutions, in which the ketone (CET???1·10?5–1·10?3 M) or enol (CET ??1·10?5 M and ??1·10?3 M) tautomers of curcumin predominate are established. In premicellar ethonium solutions, curcumin dissolves mainly in the ketone form, and in micellar medium, it dissolves in the enol form. The degree of increase in the solubility of curcumin in the presence of ethonium is characterized by the value of the solubilisation capacity of surfactant in relation to this polyphenol, which is of 0.027. The binding constant of the supramolecular curcumin–ethonium complex is determined: Kb???2.5·104 l/mole (lgKb???4.39???0.02). The revealed regularities have significant the scientific and applied importance and can be used in the development of more effective drugs containing bioactive curcumin and the antiseptic ethonium

KEY WORDS: curcumin, ethonium, solubilisation, spectrophotometry, keto-enol tautomerism

DOI:  https://doi.org/10.15407/nnn.22.04.1053

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