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O. V. Savvova and O. I. Fesenko
«Formation of Apatite-Like Layer on the Surface of Nanostructured Calcium–Phosphate–Silicate Coatings on Titanium Alloys»
649–662 (2017)

PACS numbers: 68.35.bj, 68.37.Hk, 78.30.-j, 81.05.Pj, 82.80.Gk, 87.85.jj, 87.85.Qr

The prospect of creating bioactive nanostructured glass–ceramic coatings on titanium alloys with a shortened resorption time by forming apatite-like structures on their surfaces for one month is confirmed. Criteria for the development of glass–ceramic coatings on titanium alloys for dental prosthetics are selected. The choice of the R2О–RO–CaF2–R2O3–P2O5–SiO2 system is justified. Within the boundaries of the chosen system, model glasses and coatings based on a slip technology are synthesized. Based on the data on both the crystallization ability and the solubility level of the glass–ceramic materials, the optimum glass–crystalline titanium coating is chosen. The features of formation of the nanostructure of the selected calcium phosphatesilicate glass at the initial stages of nucleation are investigated. The presence of the sibotoxic metaphosphate and hydroxide groups in the glass melt and the formation of nuclei of crystalline phases by the mechanism of spinodal decomposition upon cooling of the glass are established. This one will allow forming a hardened fine-dispersed oriented structure of glass–ceramic coatings containing hydroxyapatite (НА) and fluoroapatite of about 40 vol.% under conditions of low-temperature short-term heat treatment. The mechanism of formation of the apatite-layer on the surface of the experimental calcium phosphatesilicate coating for a month in vitro is determined, namely: formation of silica gel layer; formation of nanostructures of spherulites of amorphous calcium phosphate and their fusion; formation of a stratified structure characteristic for the nonstoichiometric HA with a ratio Ca:P=1.67. The apatite-like layer formation in the shortened time interval is realized upon this mechanism due to the peculiarities of the glass–ceramic-coating structure. The proliferation rate of mesenchymal stem cells on the surface of the prototype is analysed. Significant dynamics of their growth is evidence of the manifestation of the osteoconduction phenomenon on the selected glass–ceramic coating surface on the 7th day already is established. This fact makes it possible to recommend a synthesized glass–ceramic coating for the creation of a bioengineering structure in the development of dental implants with accelerated bone splicing.

Key words: calcium phosphatesilicate materials, glass–ceramic coatings, apatite-like layer, nanostructure, bulk fine-grained crystallization.

https://doi.org/10.15407/nnn.15.04.0649

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