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Collection of scientific works Nanosystems, nanomaterials, nanotechnologies Year 2025 Volume 23, Issue 2
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vol. 23 / 

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M. A. ZABOLOTNYY1, L. I. ASLAMOVA1, G. I. DOVBESHKO2, O. P. GNATYUK2, V. Yu. POVARCHUK2, D. S. LEONOV3, R. V. LYTVYN3,7, and M. Yu. BARABASH3–6

1Taras Shevchenko National University of Kyiv, 64, Volodymyrs'ka Str., UA-01033 Kyiv, Ukraine
2Institute of Physics, N.A.S. of Ukraine, 46, Nauky Ave., UA-03028 Kyiv, Ukraine
3Technical Centre, N.A.S. of Ukraine, 13, Pokrovs'ka Str., UA-04070 Kyiv, Ukraine
4Gas Institute, N.A.S. of Ukraine, 39, Degtyarivs'ka Str., UA-03113 Kyiv, Ukraine
5National Technical University of Ukraine 'Igor Sikorsky Kyiv Polytechnic Institute', 37, Beresteiskyi Ave., UA-03056 Kyiv, Ukraine
6Institute for Applied Control Systems, N.A.S. of Ukraine, 42, Academician Glushkov Ave., UA-03187 Kyiv, Ukraine
7I. M. Frantsevych Institute for Problems of Materials Sciences, N.A.S. of Ukraine, 3, Omeljan Pritsak Str., UA-03142 Kyiv, Ukraine

Modification of Optical Spectra and Cytostasis of Doxorubicin and Conium Solutions with High-Energy Electron Irradiation

489–500 (2025)

PACS numbers: 33.20.-t, 78.20.Ci, 78.40.Me, 78.67.Bf, 87.19.xj, 87.53.Bn, 87.64.km

The characteristics of optical absorption and cytostatic activity under high-energy electron irradiation of a solution of doxorubicin (of anthracycline class) in sodium chloride are studied. The energy of irradiating electrons was of 1 MeV, and the absorbed dose was within 2–90 kGy. As proven, when sodium chloride is irradiated, the absorbed dose affects the optical absorption spectra of samples and leads to an increase in the cytostatic effect of the drug. As shown, the optical spectra and cytostatic activity change with time in a co-ordinated manner. The dissolution of conium (of alkaloid class) in irradiated sodium chloride causes shifts of the maxima of the infrared absorption spectra of conium. A possible reason for the changes in solution properties, when using pre-irradiated sodium chloride, is the conformational rearrangement of the antitumour drug molecules. This effect can be caused by the interaction with bubbstons and their clusters, which are formed under the impact of irradiation.

KEY WORDS: NaCl, doxorubicin, conium, bubbstons, optical absorption, high-energy electrons, radiation dose, cytotoxicity

DOI:  https://doi.org/10.15407/nnn.23.02.0489

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