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W.M. ABD EL-KADER, R. ABO-GABAL, A.M. ABDELGHANY, and A.H. ORABY

Enhanced Efficiency of Samarium-Doped TiO2 Nanoparticles for Targeted Imaging: Characterization and in vivo Evaluation
535–555 (2024)

PACS numbers: 68.37.Lp, 78.55.-m, 87.63.L-, 87.64.Cc, 87.64.km, 87.64.mh, 87.85.jj

In this study, we synthesize samarium-doped TiO2 nanoparticles (Ti(Sm)O2 NPs) using solvothermal synthesis and enhance their stability and biocompatibility by coating them with polymeric materials. Extensive characterization studies confirm the desired morphology, crystal structure, optical properties, surface charge, and biocompatibility of the Ti(Sm)O2 NPs. Additionally, in vivo imaging evaluations reveal their excellent imaging capabilities, particularly, in distinguishing lung pathologies, making them highly promising for targeted imaging applications. Importantly, in vivo toxicity studies demonstrate the biocompatibility and safety of the nanoparticles. These findings contribute to the development of advanced contrast agents for improved diagnostic imaging in biomedical applications, offering potential as effective tools for targeted imaging and enhancing the diagnosis and monitoring of various lung pathologies

KEY WORDS: nanoparticles, contrast agents, K-edge, titanium oxide, biocompatibility

DOI:  https://doi.org/10.15407/nnn.22.03.535

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