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D.M. NOZDRENKO, O.P. MOTUZYUK, O.V. DOLHOPOLOV, I.V. PAMPUKHA, K.I. BOGUTSKA, and Yu.I. PRYLUTSKY

C60 Fullerene Improves Nerve Conduction After Muscle Atrophy
517–525 (2024)

PACS numbers: 81.16.Fg, 82.39.Jn, 87.16.dp, 87.16.dr, 87.16.Tb, 87.19.Ff, 87.19.xn

Nerve conduction under stimulation of the rat muscle soleus after long-term immobilisation of the hind limbs is studied using a clinical model—the rupture of the Achilles tendon. The analysis of mechanokinetic parameters of muscle contraction is performed on day 45 after the initiation of atrophy. The water-soluble C60 fullerene is used as a therapeutic nanoagent at a daily oral dose of 1 mg/kg during the experiment. The delay in the time of muscle contraction caused by 1 Hz and 2 Hz stimulations reveals a sharp increase from 98±6 ms in control to 443±8 ms and 487±7 ms after atrophy initiation, respectively. This delay is associated with a decrease in the conductivity of the nerve stimulus due to destructive changes in the nervous tissue caused by muscle atrophy. In all the tests performed with the therapeutic administration of water-soluble C60 fullerenes, an increase in nerve conduction by 31±2% and 36±2% at 1 Hz and 2 Hz stimulation, respectively, is detected in relation to the atrophy group. This indicates the presence of compensatory activation of the endogenous antioxidant system by C60 fullerenes in the process of dystrophic changes caused by prolonged immobilisation

KEY WORDS: muscle soleus, muscle atrophy, mechanokinetics of muscle contraction, C60 fullerene

DOI:  https://doi.org/10.15407/nnn.22.02.517

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