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vol. 22 / 

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M.A. ZABOLOTNYI, L.I. ASLAMOVA, H.I. DOVBESHKO, O.P. HNATIUK, H.I. SOLIANYK, V.P. DANKEVYCH, D.S. LEONOV, M.Yu. BARABASH, and V.A. CHERNIAK

The Effect of High-Energy Electron Irradiation of Saline Solution on Its Optical Characteristics and Cytotoxic/Cytodynamic Activity
481–499 (2024)

PACS numbers: 33.20.Kf, 33.20.Lg, 42.50.Gy, 78.40.Me, 87.19.xj, 87.53.-j, 87.64.kv

The work investigates the processes determining the characteristics of the method of increasing the effectiveness of the antitumor effect of doxorubicin without the use of extraneous nanoimpurities. The method is based on the use of high-energy electron irradiation of physiological saline (PS) before dissolving doxorubicin in it. The energy of the irradiation electrons is equal to 1 MeV, and the absorbed dose (gray) is in the range of 4–80 kGy. Doxorubicin (Sigma, USA) is used in the study, and the Lewis lung carcinoma cell line (LLC) given by the R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (IEPOR), National Academy of Sciences of Ukraine is used to determine the pharmacological characteristics of doxorubicin. It is proven that the amount of the absorbed dose affects the optical absorption and fluorescence spectra of the samples and leads to an increase in the cytotoxic/cytostatic effect of the drug, which is most pronounced at relatively low concentrations. The number of live LLC cells under the influence of doxorubicin in the irradiated solvent at concentrations less than 3 µM is decreased to 15% compared to the corresponding indicator under the action of doxorubicin without irradiation of the solvent. A comparative study of the acute toxicity of irradiated PS is carried out. The results of the study do not provide convincing data that would indicate differences in the toxicity profiles of irradiated and non-irradiated PSs

KEY WORDS: physiological salt solution, doxorubicin, bubstones, electron irradiation, cytotoxicity, fluorescence, extinction

DOI:  https://doi.org/10.15407/nnn.22.02.481

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