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2024

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vol. 22 /

issue 1

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AHMED FILAYIH HASSAN

Preparation and Characterization of Nanofilm-Coated Modified Electrodes and Their Use in Valsartan Drug Analysis
197–207 (2024)

PACS numbers: 68.37.Hk, 68.37.Ps, 82.35.Np, 82.45.Yz, 87.64.Dz, 87.80.Dj, 87.85.Rs

The use of nanomaterials is a modern trend in electrochemical analysis because of the ease and accuracy of the analysis that, in addition, being non-destructive to the samples, gives the possibility of repeating the analysis to obtain better results. In this research, films of a co-conductive polymer of pyrrole and one of its derivatives are fabricated by docking on a graphite substrate. The film and the substrate form a modified electrode described by EIS and CV in the presence and absence of valsartan. Using a modified electrode, the concentration of valsartan is determined in titres and blood samples of patients with a standard deviation (SD=0.6). The quantitative and detection limit are LOQ=6 µM and LOD=1.8 µM, respectively. DPV with standard addition method has standard deviation (SD=0.34). The new method succeeds in being more accurate with LOQ=3.4 µM and LOD=1.1 µM, respectively. F-test proves that the HPLC method is not better than DPV and DPV with modified standard addition methods in determining the drug concentration of valsartan. The modified standard addition method is probably the best

KEY WORDS: polymer thin films, anchoration, modified electrode, differential pulse voltammetry, valsartan

DOI: https://doi.org/10.15407/nnn.22.01.197

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