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O. P. MOTUZIUK, D. M. NOZDRENKO, K. I. BOGUTSKA, N. E. NURISHCHENKO, V. L. OSETSKIY, and Yu. I. PRYLUTSKYY
Biomechanical Parameters of the Development of Fatigue Processes in the Muscle gastrocnemius of Rats After Chronic Alcoholization and the Usage of Water-Soluble C60 Fullerenes
899–908 (2023)
PACS numbers: 81.16.Fg, 87.16.dp, 87.16.dr, 87.16.Tb, 87.19.Ff, 87.19.R-, 87.85.G-
Biomechanical changes in the contraction of the muscle gastrocnemius of rats after chronic alcoholization for 3, 6, and 9 months are studied. Oral consumption of water-soluble C60 fullerenes at a dose of 1 mg/kg is used as a corrective agent throughout the experiment. Administration of the drug in the experimental groups is carried out in three ways: 1 h before drinking alcohol, together with alcohol, and 1 h after drinking alcohol. It is established that the usage of water-soluble C60 fullerenes reduces the time of fatigue processes in alcoholised muscle by 11–39% and is most effective in the long-term development of alcoholic myopathy. The positive effect of the drug in the therapeutic regimen of usage (together with alcohol) exceeded by 6–10% its effect in prophylactic (1 h before alcohol consumption) and therapeutic (1 h after alcohol consumption) regimens, the difference in effects between which is not observed.
Key words: muscle gastrocnemius, alcohol intoxication, C60 fullerene, biomechanical parameters of skeletal muscle contraction.
Issue DOI: https://doi.org/10.15407/nnn.21.04.899
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