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Ali Alasmi, Joumaa Merza, Mirna Jabbour, and Shaimaa Rabah
Synthesis and Characterization of 2-(Aminothiazole-4-yl) Coumarin-2-One, and Studying Its Nanoparticles as Antibacterial Activity
1037–1045 (2022)

PACS numbers: 68.37.Hk, 81.16.Be, 82.39.Wj, 87.19.xb, 87.64.Ee, 87.85.Rs

The total synthesis of aminothiazole coumarin derivative (IV) in four steps is reported. The propriety of compound (IV) is studied. To evaluate the biological activity of the Schiff base (IV), the nanoparticles in solution and the nanoparticles carried on cellulose membrane are prepared, and their antibiotic activity is evaluated in two cases in comparing with the antibiotic activity of the ampicillin as a reference antibiotic. The compound (IV) shows an antibacterial activity about 50% in comparing to the ampicillin. The nanoparticles in solution have a higher antibiotic activity at lower concentrations than at high concentrations. The nanoparticles carried on cellulose membrane show a high activity about 50% in comparing to the activity of the ampicillin.

Key words: 1.3-thiazole, Schiff base, nanoparticles, membrane, antibiotics.

https://doi.org/10.15407/nnn.20.04.1037

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