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V. O. Vekshyn, L. P. Abramova, and E. R. Grabovetska
The State of Antioxidant Systems and Lipids’ Peroxidation Under the Action of Complex Substances
1017–1027 (2022)

PACS numbers: 81.16.Fg, 82.39.Fk, 82.39.Rt, 87.14.ej, 87.15.mq, 87.19.X-, 87.50.sg

The article presents the prospects for nanomaterials’ application in medicine, biology, and pharmacology. The possibility of nanoparticles’ usage as contrast agents for tomography, luminophores, and biologically active substances is shown. At the same time, the potential toxic effect on living organisms of the concerned substances is indicated, in particular, the possibility of free-radicals’ formation. These substances are capable of triggering the chain reaction of free-radicals’ transformations, which can result in the development of pathological processes. To clarify this issue, effects of the complex substance composed of lanthanides’ nanoparticles on the biochemical parameters of free-radical processes have been studied in experiment. The results show that infusion of the preparation induces an increase in the content of diene conjugates and TBA-reactive products. Moreover, the content of sulfhydryl groups reduces significantly as compared with the intact group. Catalase activity also decreases, while superoxide dismutase activity increases. Thus, the results show that the substance concerned affects the processes of free-radical oxidation. However, the effect depends on a number of factors, and additional studies are needed to determine the contribution of each of them.

Key words: nanoparticles, lanthanides, toxicity, radicals, enzymes.

https://doi.org/10.15407/nnn.20.04.1017

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