Issues

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2022

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vol. 20 /

Issue 2

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Quoc Thong Phan, Chi Thang Nguyen, and Huu Nguyen Luu
Magnetic-Liquid Nanosystems Fe₃O₄/PLA–PEG: Potential Applications in Cancer Thermotherapy
0577–0590 (2022)

PACS numbers: 78.67.Ve, 81.07.Pr, 81.70.Pg, 82.35.Np, 87.19.xj, 87.64.Ee, 87.85.Rs

In recent years, magnetic-liquid nanosystems (MNLs) have been of interest to biomedical applications. The Fe₃O₄/PLA–PEG MLNs with Fe₃O₄ magnetic nanoparticles’ core coated by PLA–PEG copolymer are used based on their nontoxicity, biocompatibility, and ability to increase heat based on the alternating external magnetic field. The Fe₃O₄/PLA–PEG MLNs of poly(lactide)–polyethylene glycol (PLA–PEG) with PLA:PEG (3:1, w/w) component ratio were fabricated by ring-opening polymerization of lactide for preparation. In particular, the sample in vitro investigation achieved a high induction heating effect that indicates the applicability of the Fe₃O₄/PLA–PEG MLNs incorporated magnetic induction hyperthermia (MIH) treatment. From this work, we believe that Fe₃O₄/PLA–PEG MLNs exhibit great potential properties for biomedical applications.

Key words: PLA–PEG copolymer, Fe₃O₄ nanoparticles, Fe₃O₄/PLA–PEG magnetic-liquid nanosystems, magnetic induction hyperthermia treatment.

https://doi.org/10.15407/nnn.20.02.577

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