Issues

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2022

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vol. 20 /

Issue 1

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I. Petryk, A. Kravchenko, A. Eremenko, O. Oranska, A. Rudenko, T. Hryts, M. Malysheva, L. Shtanova, P. Yanchuk, and O. Tsymbalyuk
Properties of Haemostatic Powders Based on Dispersed Silica, Sodium Alginate and Silver Nanoparticles
0221–0233 (2022)

PACS numbers: 61.05.cf, 61.05.cp, 78.40.-q, 78.67.Sc, 81.07.Wx, 87.64.Cc, 87.85.Rs

The compositions with pronounced haemostatic and bactericidal properties based on nanodispersed silica with sodium alginate (10% SiO₂) and silver nanoparticles (NPs) or Ag ions (0.02–23% wt.) are synthesized. As revealed, the presence of silica in the matrix of sodium alginate promotes the formation of silver NPs of smaller size and prevents their agglomeration. The bactericidal action of hybrid composites against a whole number of bacteria (E. coli, K. pneumoniae, P. aeruginosa, S. aureus, C. albicans) is determined; it correlates with the number of released Ag ions from the surface of powders upon their contacting with water and is optimal at an Ag content of 3%. In experiments on rats with parenchymal bleeding, high haemostatic activity of obtained powder compositions is demonstrated.

Key words: nanodispersed silica, silver nanoparticles, sodium alginate, surface-plasmon resonance, bactericidal activity, haemostatic properties.

https://doi.org/10.15407/nnn.20.01.221

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