Issues

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2021

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vol. 19 /

Issue 3

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D. M. Nozdrenko, Wang Nan, O. P. Motuziuk, O. V. Vygovska, K. I. Bogutska, P. Yu. Drozd, Yu. I. Prylutskyy
«Application of Stimulatory Markers for the Analysis of C\(_{60}\)-Fullerene Therapeutic Effect on the Muscle Contraction Dynamics of Chronic Alcoholic Rats »
0767–0777 (2021)

PACS numbers: 81.16.Fg, 82.39.Jn, 87.16.dp, 87.16.dr, 87.16.Tb, 87.19.Ff, 87.85.Rs

The effect of C\(_{60}\) fullerene aqueous solution on the dynamic parameters of skeletal muscle contraction of chronic alcoholic rats with duration of alcoholization of 2, 4 and 6 months is studied. C\(_{60}\) fullerene at a dose of 1 mg/kg is administered intraperitoneally during the last five days of alcoholization. Changes in the time of onset of muscle strength response are used as a marker to assess the level of myocyte damage and the severity of alcoholization in experimental animals. A pronounced protective effect of C\(_{60}\) fullerene aqueous solution on the dynamics of muscle contraction with the development of alcoholic myopathy in animals is revealed that allows its use as a principally new drug in the treatment of muscle pathologies.

Keywords: skeletal muscle, dynamics of muscle contraction, C60 fullerene, chronic alcoholic rats

https://doi.org/10.15407/nnn.19.03.767

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