vol. 18 / 

Issue 2


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O. Eu. Sych, A. P. Iatsenko, T. V. Tomila, O. I. Bykov, A. Chodara, R. Mukhovskyi, J. Mizeracki, S. Gierlotka, W. Lojkowski, Y. I. Yevych
«Effect of Chitosan Coating on the Structure and Properties of Highly-Porous Bioceramic Scaffolds for Bone Tissue Engineering»
437–447 (2020)

PACS numbers: 61.05.cp, 68.37.Hk, 81.05.Rm, 81.20.-n, 87.15.La,, 87.85.Lf

Highly-porous bioceramic scaffolds based on biogenic hydroxyapatite with addition of 40 wt.% of glass (wt.%: 45.7 SiO\(_2\), 28.2 B\(_2\)O\(_3\), 26.1 Na\(_2\)O) were prepared by foam replication method at 700\(^{\circ}\)C followed by coating of chitosan dissolved in 1% acetic acid solution and drying at 50\(^{\circ}\)C. Bioceramic samples were studied by XRD, IR spectroscopy and SEM. Phase composition, morphology, skeleton density, porosity, compression strength and in vitro tests were evaluated. The results show that, during sintering, the biogenic hydroxyapatite in bioceramic composition is stable and keeps hydroxyapatite phase without secondary phase formation. Chitosan coating shows twofold increase in the compression strength in comparison with pure bioceramics. Moreover, chitosan coating significantly influences on the structure of highly-porous bioceramic scaffolds and dissolution rate in saline. Thus, balanced porosity and compression strength and dissolution rate make the prepared materials promising for bone marrow stromal cell loading, drug delivery and bone tissue engineering application.

Keywords: hydroxyapatite, chitosan, highly-porous material, foam replication method, biomaterial

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