vol. 18 / 

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D. N. Nozdrenko, T. Yu. Matvienko, O. V. Vygovska, V. M. Soroca, K. I. Bogutska, N. E. Nuryshchenko, Yu. I. Prylutskyy, . V. Zholos
«Activation of the Cold and Menthol Receptor TRPM8 Improves Post-Traumatic Recovery of Rat Muscle Soleus During Fullerene Treatment»
205–216 (2020)

PACS numbers: 81.16.Fg, 82.39.Jn, 87.16.dp, 87.16.dr, 87.16.Tb, 87.19.Ff, 87.64.kv

The biomechanical parameters of muscle soleus of rats during the first 3 days of development of the posttraumatic syndrome caused by destruction of muscle cells by means of the mechanical compression are studied. Injections of both C60 fullerene antioxidant and menthol, which is the selective agonist of TRPM8 cold receptors, are used as therapeutic agents. Injections of an aqueous colloidal solution of C60 fullerene (at concentration of 1 mg/kg) into the damaged muscle improve its contractile function by 2530%. Application of combined injections of C60 fullerene and menthol (at concentration of 1 mkg/kg) improve this indicator by an extra 1719%, while stabilizing the decrease in muscle strength observed throughout all experiments. The revealed synergy effect of menthol and aqueous solution of C60 fullerene on posttraumatic process of restitution of skeletal muscle function opens up new prospects for the clinical application of such a combined therapy.

Keywords: muscle soleus, muscular contraction, muscle injury, C60 fullerene, menthol, therapy

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