Issues

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2018

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vol. 16 / 

Issue 4

 



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D. Ì. Nozdrenko, K. I. Bogutska, Î. Yu. Àrtemenko, N. Ye. Nurishchenko, and Yu. I. Prylutskyy
«Impact of Water-Soluble \(C_{60}\) Fullerenes on the Mechanokinetic Features of Formation of a Smooth Tetanic Contraction of Ischemic Skeletal Muscle of Rats»
745–755 (2018)

PACS numbers: 81.16.Fg, 82.39.Jn, 87.16.dp, 87.16.dr, 87.16.Tb, 87.19.Ff, 87.64.kv

With the use of tensometry, the influence of water-soluble \(C_{60}\) fullerenes on the mechanokinetic features of formation of a smooth tetanic contraction of ischemic muscle (muscle soleus) of rats is studied. Obtained results on the change in the maximal muscle force response and the time of its development at the therapeutic action of \(C_{60}\) fullerenes indicate a significant protective effect of these unique nanostructures, in particular, membranes of myocytes while maintaining adequate functioning of Ca2+ pumps, which provide the process of active muscle contraction and relaxation. The revealed therapeutic effect of \(C_{60}\) fullerenes on the mechanokinetics of smooth tetanic muscle contractions is most effective at ischemic for 1 h that makes it possible to develop the nanotechnology of using water-soluble \(C_{60}\) fullerenes as powerful antioxidants in the therapy at the early stages of ischemic damage of skeletal muscles.

Keywords: \(C_{60}\) fullerene, skeletal muscle, ischemia, force of contraction

https://doi.org/10.15407/nnn.16.04.745

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