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Iu. V. Danylovych, Н. V. Danylovych, O. V. Kolomiets, R. V. Rodik, V. I. Kalchenko, S. O. Kosterin
«Effect of Calix[4]arenes on Ca2+ Transport, Electric Potential and Functioning of the Electron Transport Chain in Smooth Muscle Mitochondria»
365–371 (2017)

PACS numbers: 81.16.Fg, 82.39.Jn, 87.16.dp, 87.16.dr, 87.16.Tb, 87.19.Ff, 87.64.kv

Calix[4]arenes C-97 and C-99 at concentration of 100 nM inhibit the Ca2+ accumulation by isolated mitochondria from smooth muscle and reduce the concentration of these cations in the matrix. The latter is explained by the registered stimulation of electrogenic mitochondria Ca2+/H+-exchanger, which is accompanied by transient polarization of the inner mitochondrial membrane. Analysis of endogenous NADH fluorescence response of mitochondria suggests that the effect of the studied calix[4]arenes in the smooth muscle may be related to the inhibition of the respective dehydrogenases too.

Key words: calix[4]arenes, calcium ions, mitochondria, Сa2+-homeostasis, smooth muscle.

https://doi.org/10.15407/nnn.15.02.0365

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