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L. G. Babich, S. G. Shlykov, A. M. Kushnarova, O. A. Esypenko, and S. O. Kosterin
«Сalix[4]arene Chalcone Amides—The Nanosize Modulators of Polarization of Mitochondrial Membranes and Content of the Ionized Ca in Them»
193–202 (2017)

PACS numbers: 82.39.Jn, 82.39.Wj, 82.45.Tv, 87.16.D-, 87.16.Tb, 87.50.cj, 87.85.Rs

Mitochondria are known to be ‘power plants’ of cells, and thus, affect the biology of cells in general. A key factor in the mitochondria functioning is the polarization of the inner membrane. So, the search of effectors, which are able to modify the level of polarization of the inner mitochondrial membrane and the concentration of ionized Ca in the matrix of these organelles, is important from both theoretical and practical points of view. Сalix[4]arenes, due to their ability to form complexes with biologically important molecules and ions, can influence the course of various biochemical processes. As shown, the calix[4]arene chalcone amides C-136 and C-137 increase the polarization of myometrial mitochondria membranes and ionized-Ca concentration in the matrix of these organelles. The degree of calix[4]arene chalcone amides’ influence on the ionized-Ca concentration within the matrix of mitochondria depends on Са2+-accumulating activity of the mitochondria, namely, if the mitochondria accumulate Ca2? more actively, there is the greater calix[4]arene chalcone amides’ impact. As suggested, the calix[4]arene chalcone amides C-136 and C-137 might be useful when mitochondria membrane potential and ionized-Ca concentration corrections are required.

Key words: calix[4]arene, polarization of mitochondria membranes, ionizedCa concentration within the mitochondria matrix.

https://doi.org/10.15407/nnn.15.01.0193

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