Скачать полную версию статьи (в PDF формате)

O. M. Otychenko, T. Ye. Babutina, O. R. Parkhomey, L. S. Protsenko, O. M. Budylina, and I. V. Uvarova
«Features of Adsorption of Drugs of Various Molecular Weight by the Biogenic Hydroxyapatite Doped with a Nanomagnetite»
185–192 (2017)

PACS numbers: 61.43.Gt, 68.37.Hk, 68.43.Mn, 75.50.Tt, 81.05.Rm, 81.20.Ev, 87.85.jj, 87.85.Rs

The work is concerned with studying the possibility for using the porous ceramics of medical application on the base of biogenic hydroxyapatite doped with nanomagnetite prepared via the condensation physicochemical methods as a carrier of drugs with varying molecular weight and, particularly, broad-spectrum antibiotics. A significant increase of solubility rate in inorganic model medium and a slight decrease of adsorption activity of doped samples in comparison with the initial one as with indicator and with an antibiotic are revealed.

Key words: biogenic hydroxyapatite, biosolubility, microstructure, adsorption activity, Ceftriaxon.

https://doi.org/10.15407/nnn.15.01.0185

REFERENCES

1. R. A. Perez, J. Won, J. C. Knowles, and H. Kim, Advanced Drug Delivery Reviews, 65: 471 (2013). https://doi.org/10.1016/j.addr.2012.03.009
2. D. Rohanova, D. Horkavcova, A. Helebrant, and A. R. Boccaccini, Journal of Non-Crystalline Solids, 432: 53 (2016). https://doi.org/10.1016/j.jnoncrysol.2015.03.016
3. J. Oliva, J. Cama, J. L. Cortina, C. Ayora, and J. De Pablo, Journal of Hazardous Materials, 213: 7 (2012). https://doi.org/10.1016/j.jhazmat.2012.01.027
4. O. M. Otychenko, O. R. Parkhomey, and I. V. Uvarova, Nanostrukturnoe Materialovedenie, 1: 86 (2015) (in Ukrainian).
5. N. V. Kerymkulova, I. Y. Torshyn, and O. A. Gromova, Reproduktivnaya Endokrinologiya, 12, No. 4: 101 (2014) (in Russian).
6. E. M. Khodosh, Novosti Meditsiny i Farmatsii, 310: 1 (2010) (in Russian).
7. V. I. Cherniy, A. N. Kolesnikov, and I. V. Kuznetsova, Novosti Meditsiny i Farmatsii, 343: 1 (2010) (in Russian).
8. O. Otychenko, A. Parkhomey, T. Babutina, and I. Uvarova, Abstr. of the 5-th Int. Conf. 'HighMathTech' (Oct. 5-8, 2015, Kyiv) (Kyiv: 2015), p. 204.
9. O. Otychenko, N. Pinchuk, O. Parkhomey, O. Kuda, and I. Uvarova, Nanostrukturnoe Materialovedenie, 2: 45 (2014) (in Ukrainian).