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С. А. Уласевич, А. И. Кулак, О. Н. Мусская, С. К. Позняк, Е. В. Скорб
«Анодные покрытия на основе высокоупорядоченных диоксид-титановых нанотрубок в качестве носителя лекарственных веществ»
181–187 (2014)

PACS numbers: 61.46.Fg, 61.46.Np, 68.37.Hk, 78.67.Ch, 78.67.Rb, 81.07.De, 82.45.Yz

Highly-ordered TiO2 nanotubes with vertical pores having a diameter of 50–80 nm and a specific internal pore surface area of about 70–80 cm2 per 1 cm2 or geometric-surface area are obtained by anodic oxidation of titanium in an ammonium-fluoride ethylene-glycol solution. Biological tests using MC3T3-E1 osteoblasts show that cells adsorbed on the surface of TiO2 nanotubes retain the ability to reproduce and to form cell–cell contacts. Titanium dioxide coatings are characterized by a high hydrophilicity (with a contact angle of 5.6?0.3?) and bioactivity. These coatings are promising for fabrication of titanium implants and as nanocontainers of antibiotics (tetracycline, doxorubicin), providing a controllable release during the treatment of bone infections.