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О. М. Якимчук, О. М. Перепелиціна, О. Д. Рудь, І. М. Кір’ян, М. В. Сидоренко
«Дослідження впливу мікроструктури наноматеріалів на утворення пухлинними клітинами багатоклітинних сфероїдів»
757–768 (2013)

PACS numbers: 61.48.De, 68.37.Lp, 68.55.ap, 81.05.U-, 87.15.-v, 87.19.xj, 87.64.-t

The effect of different concentrations of superstructural materials, namely, onion-like carbon (onions), ultradispersed diamonds (UDD), and fullerenes (С60), on the formation of multicellular spheroids is investigated. Chemical composition and purity of nanomaterials are controlled by the Fourier IR spectroscopy. The strength and direction of the impact of nanomaterials on the cell population are determined, using the Pearson’s correlation coefficient. The results demonstrate that the UDD and onions reduce adhesion and cohesive abilities of cells and stimulate fabrication of high number of cell spheroids of about 10?3 mm3. The fullerenes reduce cell adhesion to the substrate and cause the formation of cell aggregates larger than 4?10?3 mm3. These results can be useful for achievement of the directed cell growth in three-dimensional culture.

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