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N. V. MAKSYMCHUK
«Processes of Interaction of Biochemical Complexes with Surface of Nanocrystalline Cerium Oxide Film»
813–824 (2009)

PACS numbers: 81.07.Bc, 82.47.Rs, 82.65.+r, 85.30.Tv, 87.80.Kc, 87.80.Qk, 87.85.fk

Physical and chemical processes, which take place on the surface of nanocrystalline cerium-oxide thin film during interaction with biochemical complexes, are studied using site-binding theory. Ion selective field effect transistors (ISFETs) with the nanocrystalline CeOх dielectric layer are investigated for the creation of sensitive, stable, and reliable biosensors. Investigation of transfer and output parameters of ISFETs with different types of the dielectric layer (SiO2–Si3N4 and CeOх) shows an increase in pH-sensitivity by drain current of ISFET with CeOх dielectric layer caused by high density of the sensitive sites on the CeOх surface (up to 1020 m?2), high dielectric constant (????26) and energy gap (3.6 eV) of cerium oxide with a consequent reduction of loss current through dielectric. The results of application of the ISFETs with CeOх nanocrystalline film in highly-specialized immune biosensors for toxicity determination are presented. Operating principle of such sensors is based on PH change as a result of formation of immune complex between antibody and micotoxin.