Ñêà÷àòü ïîëíóþ âåðñèþ ñòàòüè (â PDF ôîðìàòå)
A. L. GABCHAK, L. N. NOSACH, and E. F. VORONIN
«Mechanical Sorption Modification of Highly Refined Sil-ica by 2-(4-Isobutylphenyl)Propionic Acid, 1-(beta-Oxyethyl)-2-Methyl-5-Nitroimidazole and Semicarbazone 5-Nitro¬phurol»
503–508 (2008)
PACS numbers: 68.43.Hn, 78.30.-j, 78.66.Vs, 81.05.Je, 81.07.Pr, 81.20.Rg, 82.70.Rr
The effect of mechanical treatment of mixtures of highly-refined silica
(Ssp???230 m2/g) with pharmaceutical substances—ibuprofen, metronidazole
and furacin—on their interaction with sorbent (silica surface) is studied by
IR spectroscopy. The realization of all possible types of interaction of drugs
with silica surface is shown: 1) the formation of homogeneous mechanical
mixture (furacin); 2) partial adsorption (metronidazole); 3) full transfer of
drug from condensed state to the surface (ibuprofen). As noted, the ability of
studied compounds to adsorption in the conditions of mechanical treatment
correlates with their solubility in ethanol.
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