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2008

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( PDF )

A. L. GABCHAK, L. N. NOSACH, and E. F. VORONIN
«Mechanical Sorption Modification of Highly Refined Sil-ica by 2-(4-Isobutylphenyl)Propionic Acid, 1-(beta-Oxyethyl)-2-Methyl-5-Nitroimidazole and Semicarbazone 5-Nitrophurol»
503–508 (2008)

PACS numbers: 68.43.Hn, 78.30.-j, 78.66.Vs, 81.05.Je, 81.07.Pr, 81.20.Rg, 82.70.Rr

The effect of mechanical treatment of mixtures of highly-refined silica (Ssp???230 m2/g) with pharmaceutical substancesibuprofen, metronidazole and furacinon their interaction with sorbent (silica surface) is studied by IR spectroscopy. The realization of all possible types of interaction of drugs with silica surface is shown: 1) the formation of homogeneous mechanical mixture (furacin); 2) partial adsorption (metronidazole); 3) full transfer of drug from condensed state to the surface (ibuprofen). As noted, the ability of studied compounds to adsorption in the conditions of mechanical treatment correlates with their solubility in ethanol.

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