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P. P. GORBIK, O. O. PENTYUK, and O. I. SHTAT’KO
«Prospects for Creation of Combined Medicines Based on Highly Refined Silica»
315–330 (2008)

PACS numbers: 82.39.-k, 82.70.-y, 83.80.Lz, 87.19.-j, 87.68.+z, 87.83.+a

The physical and chemical properties of highly refined amorphous silica surface are unique, providing its numerous biological effects: high hydrophilicity, affinity to proteins, adsorption of microorganisms and a number of lowmolecular substances, mainly nitrogen-containing ones. The specified properties of amorphous silica and its ability to modulate pharmacokinetics and biotransformation of other medications under joint administration allow the use of this material not only as the medication for application and enteral therapy, but also as the matrix-carrier for the fabrication of the combined drugs. The fabrication of the combined drugs based on amorphous silica holds considerable promise for pharmacy. A number of medications (Aquasil, Siliglucan, Fitosilard, Lysosil, Lysetox, Flotoxan etc.) are now at different stages of development, preclinical and clinical trials.