Collection of scientific works Nanosystems, nanomaterials, nanotechnologies
Year 2026 Volume 24, Issue 2
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N. VENKATESWARAMURTHY1,2, R. SAMBATHKUMAR2, P. MANIVASAKAM1,2,3, and G ANANDHARAJ2,3

1J.K.K. Nattaraja College of Pharmacy, Natarajapuram, NH-544 (Salem to Coimbatore National Highway), 638183 Namakkal, Tamil Nadu, India
2The Tamil Nadu Dr. M.G.R Medical University, 69, Anna Salai, Guindy, 600032 Chennai, Tamil Nadu, India
3Vellalar College of Pharmacy, Maruthi Nagar, Thindal, 638012 Erode, Tamil Nadu, India

Development and Characterization of Stomach-Specific Gastro-Retentive Drug Delivery of Levofloxacin Hemihydrate for Helicobacter Pylori Eradication

693–705 (2026)

PACS numbers: 47.63.mh, 68.35.Np, 82.39.-k, 87.19.xb, 87.19.xu, 87.64.Ee, 87.85.Rs

Received 14 November, 2024

Helicobacter pylori (H. pylori) is a significant gastric pathogen, often linked to chronic gastritis, peptic ulcers, and various gastric cancers. Current first-line therapies, including proton pump inhibitors and antibiotics, such as clarithromycin and amoxicillin, have variable eradication success, with failure rates ranging from 5% to 50%. A major challenge in effectively treating H. pylori infections is ensuring adequate antibiotic concentration at the infection site for sustained periods. This study aims to develop a gastro-retentive drug-delivery system (GRDDS) utilizing novel mucoadhesive alginate beads containing levofloxacin hemihydrate to enhance therapeutic efficacy. Sodium alginate and carbopol 974P are employed to create beads through ionotropic gelation, facilitating prolonged drug release in the gastric mucosal environment. A standard calibration curve is developed for levofloxacin hemihydrate in 0.1 N HCl, to ensure accurate drug measurement. The formulations’ efficacy in prolonging drug retention in the stomach aims to improve H. pylori eradication rates. The results are expected to demonstrate that sustained release of levofloxacin via GRDDS increases significantly local drug concentration at the infection site, offering a promising approach to enhance the treatment outcomes for H. pylori infections. This innovative delivery system not only addresses the limitations of current treatments, but also stands to impact clinical practices in managing gastric infections effectively.

KEY WORDS: Helicobacter pylori, gastro-retentive drug delivery, levofloxacin hemihydrate, mucoadhesive alginate beads, peptic ulcers, antibiotic efficacy

DOI: https://doi.org/10.15407/nnn.24.02.0693

Citation:
N. Venkateswaramurthy, R. Sambathkumar, P. Manivasakam, and G. Anandharaj, Development and Characterization of Stomach-Specific Gastro-Retentive Drug Delivery of Levofloxacin Hemihydrate for Helicobacter Pylori Eradication, Nanosistemi, Nanomateriali, Nanotehnologii, 24, No. 2: 693–705 (2026); https://doi.org/10.15407/nnn.24.02.0693
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