Collection of scientific works Nanosystems, nanomaterials, nanotechnologies
Year 2026 Volume 24, Issue 1
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Viktor BOROVSKYI and Mykola BOGOMOLOV

National Technical University of Ukraine ‘Igor Sikorsky Kyiv Polytechnic Institute’, 37, Beresteiskyi Ave., UA-03056 Kyiv, Ukraine

Laser Speckle Analysis of Blood Coagulation: Overview and Prospects for Use in Military Medicine

301–316 (2026)

PACS numbers: 42.25.Dd, 42.30.Ms, 81.07.Bc, 83.80.Lz, 87.85.gf, 87.85.Pq, 87.85.Rs

Received 10 August, 2025; in revised form, 15 September, 2025

The article discusses a promising technology for assessing the blood-coagulation system, namely, laser speckle analysis (LSA), with an emphasis on the use of optical nanostructured components to improve the quality of diagnostics. A review of the physical foundations of the method, modern scientific research and comparison with traditional viscoelastic haemostatic assays TEG, ROTEM, ClotPro is carried out. Particular attention is paid to the role of nanotechnological solutions (anti-reflective nanocoatings of the ‘moth-eye’ type, plasmon Ag, Si nanoparticles and silver nanofilms with a thickness of 40–80 nm) in the formation of a stable, high-contrast speckle pattern. The mechanisms of reducing parasitic reflections, increasing light transmission and amplification of the local light signal due to the effects of the local and surface plasmon resonances are described. As shown, the introduction of such nanostructures into the configuration of the LSA sensor can improve significantly the signal-to-noise ratio, increase the spatial resolution and accuracy of the assessment of the microdynamics of formed blood elements. The potential of portable implementation of LSA with nanoreinforced optical elements for the field and military medicine Role 2, Role 3 is highlighted, where the applicability of conventional coagulation devices is limited. The proposed approach combines optical diagnostics and nanotechnology methods, which open up new opportunities for the creation of a new generation of mobile biomedical sensors. This work emphasizes not only the technological novelty of LSA, but also its direct clinical value for increasing the effectiveness of treatment in conditions of emergency and military medicine.

KEY WORDS: laser speckle analysis, fibre-optic light guides, blood coagulation, nanocoatings, optical diagnostics, military medicine

DOI: https://doi.org/10.15407/nnn.24.01.0301

Citation:
Viktor Borovskyi and Mykola Bogomolov, Laser Speckle Analysis of Blood Coagulation: Overview and Prospects for Use in Military Medicine, Nanosistemi, Nanomateriali, Nanotehnologii, 24, No. 1: 301–316 (2026); https://doi.org/10.15407/nnn.24.01.0301
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