Collection of scientific works Nanosystems, nanomaterials, nanotechnologies
Year 2025 Volume 23, Issue 4
Download the full version of the article (PDF, In Ukrainian / Українською) Open Access

O. M. ABRAMCHUK1, D. M. NOZDRENKO2, I. I. BARDADYM2, O. V. KROPYVA1, K. I. BOGUTSKA2, and Yu. I. PRYLUTSKYY2

1Lesya Ukrainka Volyn National University, 13, Voli Ave., UA-43025 Lutsk, Ukraine
2Taras Shevchenko National University of Kyiv, 64/13, Volodymyrska Str., UA-01601 Kyiv, Ukraine

The Effect of C60 Fullerenes on the Level of Fluctuations in the Maximum Contraction Force of the musculus gastrocnemius in Rats with Chronic Glyphosate Intoxication

1271–1278 (2025)

PACS numbers: 81.16.Fg, 87.16.dm, 87.19.Ff, 87.19.lt, 87.19.R-, 87.19.xn, 87.85.G-

Received 25 April, 2025

The change in the level of fluctuation vibrations in the phase of maintaining maximum force in 10 consecutive non-relaxation contractions of the musculus gastrocnemius of rats with chronic glyphosate intoxication for 15, 30 and 45 days is analysed. As a therapeutic agent, oral administration of C60 fullerenes at a dose of 1 mg/kg of animal weight is used daily throughout the experiment. The use of C60 fullerenes as powerful antioxidants reveals a significant decrease in the above-mentioned biomechanical marker of muscle dysfunction; the positive effect is from 35 ± 2% to 70 ± 4% compared to control. The results obtained indicate the prospects for the usage of water-soluble C60 fullerenes for restoring contractile activity of the musculus gastrocnemius against the background of chronic glyphosate intoxication.

KEY WORDS: C60 fullerene, musculus gastrocnemius, glyphosate, contraction force

DOI: https://doi.org/10.15407/nnn.23.04.1271

Citation:
O. M. Abramchuk, D. M. Nozdrenko, I. I. Bardadym, O. V. Kropyva, K. I. Bogutska, and Yu. I. Prylutskyy, The Effect of C60 Fullerenes on the Level of Fluctuations in the Maximum Contraction Force of the musculus gastrocnemius in Rats with Chronic Glyphosate Intoxication, Nanosistemi, Nanomateriali, Nanotehnologii, 23, No. 4: 1271–1278 (2025); https://doi.org/10.15407/nnn.23.04.1271
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