Collection of scientific works Nanosystems, nanomaterials, nanotechnologies
Year 2025 Volume 23, Issue 3
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D. M. NOZDRENKO1, M. S. ANGELOV1, K. I. BOGUTS'KA1, I. V. PAMPUKHA1, O. R. DMYTROTSA2, T. Ya. SHEVCHUK2, and Yu. I. PRYLUTS'KYY1

1Taras Shevchenko National University of Kyiv, 64/13, Volodymyrska Str., UA-01601 Kyiv, Ukraine
2Lesya Ukrainka Volyn National University, 13, Voli Ave., UA-43025 Lutsk, Ukraine

The Effect of Water-Soluble C60 Fullerenes on the Parameters of Smooth Tetanic Contraction of the Rats' gastrocnemius muscle after Neurogenic Atrophy

973–981 (2025)

PACS numbers: 81.16.Fg, 87.16.dr, 87.19.Ff, 87.19.lt, 87.19.R-, 87.19.xn, 87.85.G-

The biomechanical parameters of the rat muscle gastrocnemius contraction (in particular, the maximum and minimum force of a single muscle contraction) are studied after neurogenic atrophy caused by sciatic nerve transection. Their fixation is occurred on the 30th day after the initiation of the injury. As a therapeutic agent, oral administration of C60 fullerenes is used in a daily dose of 1 mg/kg throughout the experiment. The transition of the force response of the active muscle from the state of serrated tetanus to smooth one, as a marker of its dysfunction, is analysed in detail. As shown, the use of water-soluble C60 fullerenes increases the maximum force of a single contraction of the muscle gastrocnemius, bringing it closer to the control, and reduces the minimum force, causing smooth tetanic muscle contraction. The results obtained indicate the prospects of using these carbon nanostructures to recover the contractile activity of skeletal muscles after neurogenic atrophy.

KEY WORDS: C60 fullerene, muscle gastrocnemius, neurogenic atrophy, biomechanical parameters of skeletal muscle contraction

DOI: https://doi.org/10.15407/nnn.23.03.0973

Citation:
D. M. Nozdrenko, M. S. Angelov, K. I. Boguts'ka, I. V. Pampukha, O. R. Dmytrotsa, T. Ya. Shevchuk, and Yu. I. Pryluts'kyy, The Effect of Water-Soluble C60 Fullerenes on the Parameters of Smooth Tetanic Contraction of the Rats' gastrocnemius muscle after Neurogenic Atrophy, Nanosistemi, Nanomateriali, Nanotehnologii, 23, No. 3: 973–981 (2025); https://doi.org/10.15407/nnn.23.03.0973

Funding / Acknowledgments:
The research was carried out with the financial support of the Ministry of Education and Science of Ukraine [theme No. 24БП018-02, 2024–2026].

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