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NANOSISTEMI, NANOMATERIALI, NANOTEHNOLOGII Year 2025 Volume 23, Issue 1
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I.V. ZATOVSKYI, S.M. DYBKOVA, L.S. RIEZNICHENKO, O.A. TSYHANOVYCH, T.H. HRUZINA, A.V. PANKO, and V.A. PROKOPENKO

Composition of the Silver and Gold Nanoparticles as a Component of the Medicinal Product ‘Coagulox_N’

203–214 (2025)

PACS numbers: 68.37.Hk, 82.70.Dd, 83.80.Lz, 87.64.Cc, 87.64.Ee, 87.85.jj, 87.85.Rs

The paper investigates the possibilities to prepare a composition of water–alcohol extracts of unripe walnut fruits (Juglans regia L.) with the silver and gold nanoparticles. The metals' nanoparticles are synthesized by the hydrothermal method. The synthesized nanoparticles and their composition with plant extracts are characterized by the SEM and UV–Vis methods. As shown, the synthesized silver and gold nanoparticles have a spherical shape with a diameter of about 30 nm and characteristic absorption peaks at 427 nm and 528 nm, respectively. The biosafety of nanoparticles of both types is shown by Comet assay and by the influence on the Mg2+-ATPase activity of the membrane fraction of eukaryotic cells. The possibilities to prepare the composition of the silver and gold sols with the investigated extracts of unripe walnut fruits, while preserving the morphological characteristics of nanoparticles, are demonstrated. The obtained results show the possibilities to use the studied composition in the developed formulation of the means 'Koaguloks_N'

KEY WORDS: silver and gold nanoparticles, water–alcohol extract, walnut (Juglans regia L.), SEM, UV–Vis spectroscopy, biosafety

DOI:  https://doi.org/10.15407/nnn.23.01.0203

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