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«Magnetic Nanoparticles for Biomedical Purposes: Methods of Synthesis, Investigation of Properties, Applications»
1027–1059 (2009)

PACS numbers: 75.75.Cd, 81.07.-b, 81.16.-c, 81.20.-n, 82.35.-x, 82.70.-y, 87.85.-d

Synthesis of superparamagnetic nanoparticles for medical-biological applications is now intensively developed. Essential progress, especially throughout the last decade, has been achieved in the synthesis of magnetic nanoparticles that leads to the wide range of nanoparticles structure, sizes and properties. Different types of monodisperse nanocrystals with certain size, structure and physical and chemical characteristics of the particles were synthesized and modified by a wide range of chemical synthetic methods. However, synthesis of magnetic nanoparticles of high quality, namely, homodispersed population of magnetic grains with controlled size, which are stable, non-agglomerate, with the coating for various media (water, salt, cell cultures, and biological ones) remains till now a challenge. Therefore, it is necessary to develop new strategies of synthesis of nanoparticles with appropriate properties. In this review, the possible methods of synthesis of magnetite nanoparticles for medical and biological use (co-precipitation, hydrothermal and high-temperature reactions, electrochemical methods etc.), methods of synthesized magnetite-nanoparticles stabilization, methods of a nanoparticles surface modification, methods of investigation of the structure and physical and chemical characteristics of synthesized nanoparticles, the possible use of synthesized nanoparticles, and also development perspectives in the field of nanotechnology are considered.

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